Fig. 3
From: Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR
Combination treatment with AZD1775 and AZD6738 in OCCC cell lines. (A) OCCC cell lines (WT: ARID1A wild type, ES2; Mut: ARID1A mutant, KOC7C) were treated with AZD1775 or AZD6738 alone and combination of both at 0, 0.25, 0.5, 1, 2 µM (< IC50) for 72 h. Dose-response matrices and CI (combination index) heatmap between the interaction of two drugs are shown. Dose-response matrices: Red; 100% growth inhibition; White; 50%; Blue, 0%. CI’s were analyzed by CompuSyn as described in Methods. CI values: < 1, synergistic; =1, additive; > 1, antagonistic. CI < 0.3, strong synergy. (B) ARID1A isogenic ES2 OCCC cell lines (WTC : wildtype control; KD: ARID1A shRNA knockdown). Also see Supplementary Fig. 4