Gene | Gene name | Functions in OV | Reference |
---|---|---|---|
FOXO1 | Forkhead Box protein 1 | FOXO1 is essential in various intra-cellular functions, including autophagy. The phosphorylation of FOXO1 regulated by ITGA2 could regulate resistance to paclitaxel in OV | [19] |
CASP8 | Caspase 8 | The genetic variants of CASP8 could protect against carcinogenesis and delay tumor onset in OV. CASP8 inhibition could regulate cancer progression by triggering the autophagy process based on ATG3 and BECLIN-1 | |
CTSD | Cathepsin D | The overexpression of CTSD in OV tumor tissue could enhanced proangiogenic responses including angiogenic tube formation, proliferation, and migration via activation of the PI3K/AKT and ERK1/2 pathways | |
GSK3B | Glycogen synthase kinase 3 beta | The activation of ERK/GSK3β/β-catenin pathway by lipocalin2 could promote tumor cell proliferation and migration in OV | [24] |
IL1B | Interleukin 1 beta | In OV, IL1B could regulate the NF-κB pathway to induce the up-regulation of HLA-G expression, which is correlated with microenvironment tolerant immune cells, such as Tregs and the diminution of memory T and NK cells | [25] |
FLNC | Filamin C | Unknown in OV. In gastric cancer, FLNC downregulation by acetylated Siah2 could increase invasiveness of tumor cells | [26] |
PEN1 | Penetration 1 | Unknown in OV | - |
RNASEL | Recombinant Ribonuclease L | Unknown in OV. As for prostate cancer, RNASEL could mediate the proapoptotic activities of the IFN-inducible 2-5A system, which is important in prostate cancer susceptibility | [27] |
SNCA | Synuclein alpha | Unknown in OV. SNCA, a small cytoplasmic protein that involves in neurodegenerative diseases, is expressed in a high percentage of OVs | [28] |