Fig. 6

Schematic diagram of the mechanism by which CFDTW affects the PCOS with PDS. CFDTW promotes the methylation of PKP3 promoter in ovarian granulosa cells, leading to inhibition of PKP3 expression and decreased MAPK pathway activity, thereby inhibiting ERCC1 expression, promoting the proliferation of ovarian granulosa cells and inhibiting their apoptosis, and ultimately alleviating PCOS with PDS