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Table 1 Clinical characteristics of the PCOS women with singleton and twin births (Median ± IQR (range) or n (%))

From: Maternal preconception thyroid autoimmunity is associated with neonatal birth weight conceived by PCOS women undergoing their first in vitro fertilization/intracytoplasmic sperm injection

Characteristics

Singletons

N = 361

Twins

N = 125

Pa

Maternal age, years

 

31.0 (28.0, 33.0)

30.0 (28.0, 32.0)

0.06

Preconception BMI, kg/m2

 

23.9 (21.3, 27.0)

24.0 (21.5, 27.3)

0.59

AFC, n

 

16.0 (11.0, 21.0)

16.0 (12.0, 22.0)

0.24

Testosterone, nmol/L

 

0.7 (0.7, 1.1)

0.7 (0.7, 1.0)

0.90

AMH, ng/mL

 

4.9 (2.9, 7.4)

5.2 (3.5, 8.2)

0.07

Duration of infertility, years

 

3.0 (2.0, 4.0)

3.0 (2.0, 5.0)

0.81

T4, μg/dL

 

7.9 (7.0, 9.0)

8.2 (7.2, 9.2)

0.11

FT4, ng/dL

 

1.3 (1.2, 1.4)

1.3 (1.2, 1.4)

0.18

TSH, μIU/mL

 

2.1 (1.6, 2.9)

2.1 (1.6, 3.0)

0.74

TGAb, U/mL

 

15.6 (15.0, 24.6)

16.0 (15.0, 27.5)

0.54

TPOAb, U/mL

 

30.0 (28.0, 40.7)

29.4 (28.0, 43.5)

0.98

Positive TGAbb

No

308 (85.3)

105 (84.0)

0.72

 

Yes

53 (14.7)

20 (16.0)

 

Positive TPOAbb

No

319 (88.4)

110 (88.0)

0.91

 

Yes

42 (11.6)

15 (12.0)

 

Infertility type

Primary

263 (72.9)

102 (81.6)

0.05

 

Secondary

98 (27.1)

23 (18.4)

 

Ovarian stimulation regimen

GnRH antagonist

274 (75.9)

90 (72.0)

0.55

 

Long GnRHa

80 (22.2)

31 (24.8)

 
 

Othersbc

7 (1.9)

4 (3.2)

 

Insemination technique

IVF

265 (73.4)

86 (68.8)

0.35

 

ICSI

96 (26.6)

39 (31.2)

 

Timing of embryo transfer

Day 3

344 (95.3)

124 (99.2)

0.16

 

Day 5

12 (3.3)

1 (0.8)

 
 

Day 6

5 (1.4)

0 (0.0)

 

Transferred embryos number, n

1

49 (13.6)

1 (0.8)

 < 0.001

 

2

312 (86.4)

124 (99.2)

 

Gestational age, weeks

 < 37

330 (91.4)

63 (50.4)

 < 0.001

 

37 − 42

31 (8.6)

62 (49.6)

 

Delivery mode

Vaginal delivery

165 (45.7)

13 (10.4)

 < 0.001

 

Caesarean

196 (54.3)

112 (89.6)

 

Neonatal sex

Male

177 (49.0)

128 (51.2)

0.62

 

Female

184 (51.0)

122 (48.8)

 

Birth weight, g

 < 2500

17 (4.7)

130 (52.0)

 < 0.001

 

2500 − 4000

320 (88.6)

120 (48.0)

 
 

 ≥ 4000

24 (6.6)

0 (0.0)

 
  1. Abbreviations: PCOS polycystic ovary syndrome, IQR interquartile range, BMI body mass index, AFC antral follicle count, AMH anti-Müllerian hormone, T4 thyroxine, FT4 free thyroxine, TSH thyroid-stimulating hormone, TGAb thyroglobulin antibody, TPOAb thyroid peroxidase antibody, GnRH gonadotropin-releasing hormone, GnRHa gonadotropin-releasing hormone agonist, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection
  2. aP-values comparing the differences between the singleton group and the twin group
  3. bClinical reference lines of positive TGAb and TPOAb were > 60 U/mL in concentration
  4. cOther protocols include the short GnRHa protocol, ultrashort GnRH antagonist protocol, and minimal stimulation protocol clomiphene or letrozole