Maternal preconception thyroid autoimmunity is associated with neonatal birth weight conceived by PCOS women undergoing their first in vitro fertilization/intracytoplasmic sperm injection

Table 2 Associations between maternal preconception serum thyroid function and autoimmunity indicators and neonatal birth weight among PCOS women undergoing their first IVF/ICSI cycles^a

Thyroid function and autoimmunity indicators^b	Change in birth weight (95% CI), g
Thyroid function and autoimmunity indicators^b	Singletons^c N = 361	Twins^d N = 125
T4
T1	Ref	Ref
T2	− 4.50 (− 113.47, 104.50)	60.15 (− 62.10, 182.40)
T3	− 71.94 (− 184.56, 40.70)	54.47 (− 69.59, 178.50)
P for trend	0.22	0.38
FT4
T1	Ref	Ref
T2	− 29.07 (− 139.00, 80.80)	− 45.32 (− 163.11, 72.50)
T3	− 29.24 (− 139.00, 80.90)	− 80.30 (− 201.55, 41.00)
P for trend	0.59	0.19
TSH
T1	Ref	Ref
T2	− 19.22 (− 130.00, 91.90)	1.59 (− 119.50, 122.70)
T3	− 23.46 (− 135.00, 88.20)	17.77 (− 94.40, 130.00)
P for trend	0.68	0.76
TGAb
T1	Ref	Ref
T2	− 83.39 (− 206.63, 39.80)	126.25 (− 14.25, 266.80)
T3	− 32.44 (− 134.75, 69.90)	81.49 (− 22.79, 185.80)
P for trend	0.48	0.10
TPOAb
T1	Ref	Ref
T2	4.47 (− 111.15, 120.10)	8.88 (− 133.30, 151.10)
T3	− 119.72 (− 222.68, − 16.70)	138.62 (33.96, 243.30)
P for trend	0.03	0.01

^aAdjusted for maternal age (continuous), preconception BMI (continuous), gestational age, delivery mode, and neonatal sex
^bFor singleton pregnancy, the tertiles of T4 are 7.30 and 8.60 μg/dL; the tertiles of FT4 are 1.22 and 1.33 μg/dL; the tertiles of FSH are 1.69 and 2.62 μIU/mL; the tertiles of TGAb are 15.00 and 20.70 U/mL; the tertiles of TPOAb are 28.00 and 37.20 U/mL. For twin pregnancy, the tertiles of T4 are 7.80 and 8.70 μg/dL; the tertiles of FT4 are 1.24 and 1.35 μg/dL; the tertiles of FSH are 1.74 and 2.64 μIU/mL; the tertiles of TGAb are 15.00 and 22.70 U/mL; the tertiles of TPOAb are 28.00 and 38.20 U/mL
^cBased on the generalized linear model
^dBased on the generalized estimating equation

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