Fig. 4

Differential gene expression analysis and DEGs functional enrichment analysis. (A) PCA analysis of Control, POI, POI + hUMSCs and POI + PBS groups. Scatter-plot comparison showing the DGEs between (B) Control and POI groups, (C) POI + hUMSCs and POI + PBS groups. (D) Scatter-plot comparison showing the POI + hUMSCs rescued DGEs between POI up-regulated and POI down-regulated genes. (E) The heat map showing DEGs in Control, POI, POI + hUMSCs and POI + PBS groups. (F) DEGs functional enrichment analysis of the POI group compared with the control group. (n = 3)