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Fig. 1 | Journal of Ovarian Research

Fig. 1

From: Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Fig. 1

A schematic representation of the proposed mechanism by mutations in CCNB3 impairs oocyte meiotic process. The mutations affect the location of CCNB3 and affect the CDK1 activity in oocytes, resulting in partial oocytes arrest at the GV stage. Then, decreased CDK1 activity promote the level of APC/C-CDH1 and induce insufficient APC/C-CDC20 activity. Finally, the mutations cause oocyte meiotic arrest at metaphase I

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Journal of Ovarian Research

ISSN: 1757-2215

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