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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Fig. 2

Identification of mutations in CCNB3. (A) Each affected individuals carries a heterozygous mutation; Sanger sequencing confirmation is shown below the pedigrees. Black circles indicate affected individuals. The “=” sign indicates infertility. (B) Location and conservation of mutations in CCNB3. The positions of E116A and E221A mutations are indicated in exon 5, P1223L located in exon 9 and S1353N located in exon 11. The patient 1 carried mutation c.A347C p.E116A, patient 2 carried mutation c.A662C p.E221A and patient 3 carried mutation c.C3668T p.P1223L. Patient 4 and patient 5 carried the same mutation c.G4058A p.S1353A. (C) The conservation of the mutations among multiple species. (D) Morphology of oocytes retrieved from control individuals and patients. The scale bar represents 40 μm

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Journal of Ovarian Research

ISSN: 1757-2215

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