Application of comprehensive unit-based safety program model to improve chemotherapy-induced nausea and vomiting in patients with ovarian cancer: a retrospective study

Table 2 Comparison of vomiting frequency and nausea degree in acute phase between two groups

Variables	Intentional analysis				Per-protocol analysis*
Variables	The intervention group(n = 45)	The control group(n = 45)	Z	P	The intervention group(n = 41)	The control group(n = 41)	Z	P
Vomiting frequency (before intervention)	1.0(1.0,2.0)	1.0(1.0,2.0)	-0.540	0.589	1.0(1.0,2.0)	1.0(1.0,2.0)	-0.231	0.817
Vomiting frequency (after intervention)	1.0(0.0,1.0)	1.0(0.5,1.0)	-2.770	0.006	1.0(0.0,1.0)	1.0(0.0,1.0)	-2.075	0.038
Nausea degree (before intervention)	2.0(1.0,3.0)	2.0(1.0,2.5)	-1.587	0.113	2.0(1.0,2.5)	1.0(1.0,2.5)	-1.525	0.127
Nausea degree (after intervention)	1.0(0.0,1.0)	1.0(1.0,2.0)	-3.400	0.001	1.0(0.0,1.5)	1.0(1.0,2.0)	-2.375	0.018

*: Per-protocol analysis was performed on patients who completed the entire intervention. In the intervention group, 4 cases were excluded, including 2 cases transferred to hospital and 2 cases transferred to department. In the control group, 1 case was transferred to another hospital and 3 cases to another department

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