Table 1 List of included studies in the present meta-analysis
Sr. No | Study | Year | Country | PCOS diagnostic criteria | Variants Studied | Genotyping method | Sample size (Cases/Controls) |
|---|---|---|---|---|---|---|---|
1) | Conway et al. [27] | 1999 | UK | PCO + OA + MD | rs6165, rs6166 | PCR-SSCP | 93/51 |
2) | Tong et al. [28] | 2001 | China | HA + PCO + MD | rs6165 | PCR–RFLP | 124/236 |
3) | Sudo et al. [29] | 2002 | Japan | Rotterdam Criteria | rs6165, rs6166 | PCR–RFLP | 18/168 |
4) | Unsal et al. [30] | 2009 | Turkish | Rotterdam Criteria | rs6165, rs6166 | PCR–RFLP | 44/50 |
5) | Valkenburg et al. [17] | 2009 | Netherlands | Rotterdam Criteria | rs6166 | PCR-SSP | 495/2912 |
6) | Du et al. [31] | 2010 | China | Rotterdam Criteria | rs6165, rs6166 | PCR-SSP | 55/92 |
7) | Gu et al. [16] | 2010 | Korea | Rotterdam Criteria | rs6165, rs6166 | PCR–RFLP | 235/128 |
8) | Mohiyiddeen et al. [32] | 2012 | UK | Rotterdam Criteria | rs6166 | Taq man assay | 58/83 |
9) | Fu et al. [33] | 2013 | China | Rotterdam Criteria | rs6165, rs6166 | Sequencing | 384/768 |
10) | Kambalachenu et al. [34] | 2013 | India | Rotterdam Criteria | rs6166 | PCR–RFLP | 97/101 |
11) | Liaqat et al. [35] | 2013 | Pakistan | Rotterdam Criteria | rs6165, rs6166 | PCR-SSP | 96/96 |
12) | Singhasena et al. [36] | 2014 | Thailand | Rotterdam Criteria | rs6165, rs6166 | PCR–RFLP | 133/132 |
13) | Wu et al. [37] | 2014 | China | Rotterdam Criteria | rs6165, rs6166 | PCR–RFLP | 215/205 |
14) | Almawi et al. [38] | 2015 | Bahrain | Rotterdam Criteria | rs6166 | Real-time PCR | 203/211 |
15) | Thathapudi et al. [39] | 2016 | India | AES | rs6166 | PCR–RFLP | 204/204 |
16) | Kim et al. [4] | 2017 | Japan | Rotterdam Criteria | rs6165, rs6166 | Sequencing | 377/388 |
17) | Branavan et al. [40] | 2018 | Sri Lanka | Rotterdam Criteria | rs6165, rs6166 | Real-time PCR | 55/110 |
18) | Wan et al. [23] | 2021 | China | Rotterdam Criteria | rs6165, rs6166 | Sanger sequencing | 400/480 |
19) | Kaur et al. [24] | 2023 | India | Rotterdam Criteria | rs6165, rs6166 | PCR–RFLP | 421/322 |
20) | Vieira et al. [25] | 2023 | Portugal | Rotterdam Criteria | rs6166 | PCR–RFLP | 88/80 |