Table 3 Overall and subgroup analyses for the impact of dienogest pretreatment on IVF-ET outcomes in patients with endometriosis
Outcome | Overall/subgroup analysis | Number of studies | RR/WMD (95%CI) | P | I2 |
|---|---|---|---|---|---|
Clinical pregnancy rate | Overall | 5 | 1.264 (0.824, 1.939) | 0.284 | 67.0 |
Group | Â | Â | Â | Â | |
DNG vs. no treatment | 2 | 2.055 (1.275, 3.312) | 0.003 | 0.0 | |
DNG + short-acting GnRH-a vs. ultra-long GnRH-a | 1 | 1.417 (0.735, 2.732) | 0.299 | NA | |
DNG vs. long GnRH-a | 1 | 0.542 (0.321, 0.916) | 0.022 | NA | |
DNG vs. dydrogesterone | 1 | 1.078 (0.827, 1.404) | 0.579 | NA | |
Embryo | Â | Â | Â | Â | |
Frozen | 2 | 1.109 (0.854, 1.439) | 0.438 | 0.0 | |
Fresh | 3 | 1.848 (1.234, 2.767) | 0.003 | 0.0 | |
Live birth rate | Overall | 4 | 1.234 (0.659, 2.309) | 0.511 | 70.4 |
Group | Â | Â | Â | Â | |
DNG vs. no treatment | 2 | 2.136 (1.223, 3.734) | 0.008 | 0.0 | |
DNG vs. long GnRH-a | 1 | 0.441 (0.214, 0.907) | 0.026 | NA | |
DNG vs. dydrogesterone | 1 | 0.942 (0.661, 1.343) | 0.741 | NA | |
Embryo | Â | Â | Â | Â | |
Frozen | 2 | 1.112 (0.537, 2.305) | 0.775 | 27.0 | |
Fresh | 2 | 2.132 (1.090, 4.169) | 0.027 | 18.6 | |
Retrieved oocytes | Overall | 2 | -1.195 (-3.314, 0.923) | 0.269 | 79.3 |
Group | Â | Â | Â | Â | |
DNG + short-acting GnRH-a vs. ultra-long GnRH-a | 1 | -0.300 (-0.742, 0.142) | 0.183 | NA | |
DNG vs. long GnRH-a | 1 | -2.500 (-4.411, -0.589) | 0.01 | NA | |
Mature oocytes | Overall | 4 | -0.990 (-2.264, 0.285) | 0.128 | 87.3 |
Group | Â | Â | Â | Â | |
DNG vs. no treatment | 1 | 0.700 (0.015, 1.385) | 0.045 | NA | |
DNG + short-acting GnRH-a vs. ultra-long GnRH-a | 1 | -0.600 (-1.132, -0.068) | 0.027 | NA | |
DNG vs. long GnRH-a | 1 | -2.500 (-4.217, -0.783) | 0.004 | NA | |
DNG vs. dydrogesterone | 1 | -2.270 (-3.620, -0.920) | 0.001 | NA | |
Blastocysts | Overall | 2 | -1.329 (-3.284, 0.626) | 0.183 | 89.9 |
Group | Â | Â | Â | Â | |
DNG vs. no treatment | 1 | -0.400 (-0.881, 0.081) | 0.103 | NA | |
DNG vs. long GnRH -a | 1 | -2.400 (-3.549, -1.251) |  < 0.001 | NA | |
Transferrable embryos | Overall | 2 | 0.187 (-0.487, 0.862) | 0.586 | 71.3 |
Group | Â | Â | Â | Â | |
DNG vs. no treatment | 1 | -0.100 (-0.420, 0.220) | 0.076 | NA | |
DNG + short-acting GnRH-a vs. ultra-long GnRH-a | 1 | 0.600 (-0.062, 1.262) | 0.540 | NA | |
Fertilization rate | Overall | 3 | 1.029 (0.958, 1.105) | 0.429 | 0.0 |
Group | Â | Â | Â | Â | |
DNG + short-acting GnRH-a vs. ultra-long GnRH-a | 1 | 1.185 (0.807, 1.740) | 0.386 | NA | |
DNG vs. long GnRH-a | 1 | 0.788 (0.525, 1.185) | 0.253 | NA | |
DNG vs. dydrogesterone | 1 | 1.032 (0.961, 1.108) | 0.386 | 0.0 | |
Embryo | Â | Â | Â | Â | |
Frozen | 1 | 1.032 (0.961, 1.108) | 0.386 | 0.0 | |
Fresh | 1 | 1.185 (0.807, 1.740) | 0.386 | NA | |
Implantation rate | Overall | 3 | 1.111 (0.888, 1.391) | 0.356 | 42.6 |
Group | Â | Â | Â | Â | |
DNG vs. no treatment | 1 | 1.657 (1.012, 2.715) | 0.045 | 0.0 | |
DNG vs. long GnRH-a | 1 | 0.708 (0.387, 1.297) | 0.264 | NA | |
DNG vs. dydrogesterone | 1 | 1.064 (0.807, 1.403) | 0.662 | NA | |
Embryo | Â | Â | Â | Â | |
Frozen | 2 | 1.084 (0.830, 1.415) | 0.553 | 0.0 | |
Fresh | 1 | 1.849 (1.031, 3.318) | 0.039 | NA | |
Miscarriage rate | Overall | 3 | 1.384 (0.824, 2.325) | 0.220 | 6.1 |
Group | Â | Â | Â | Â | |
DNG + short-acting GnRH-a vs. ultra-long GnRH-a | 1 | 0.178 (0.009, 3.433) | 0.253 | NA | |
DNG vs. long GnRH-a | 1 | 1.455 (0.512, 4.134) | 0.482 | NA | |
DNG vs. dydrogesterone | 1 | 1.639 (0.873, 3.078) | 0.124 | NA | |
Embryo | Â | Â | Â | Â | |
Frozen | 1 | 1.639 (0.873, 3.078) | 0.124 | NA | |
Fresh | 1 | 0.178 (0.009, 3.433) | 0.253 | NA |