Fig. 8

Fance deficient PGCs down-regulated the HR pathway during rapid mitosis. (A) Representative images of co-localized staining of BLM and SSEA1 in Fance^−/− PGCs and Fance^+/+ PGCs. (B) The proportion of BLM positive cells was significantly decreased in Fance^−/− PGCs compared to Fance^+/+ PGCs. (C) Representative images of co-localized staining of RAD51 and SSEA1 in Fance^−/− PGCs and Fance^+/+ PGCs. (D) The proportion of RAD51 positive cells was significantly decreased in Fance^−/− PGCs compared to Fance^+/+ PGCs. n = 4 embryos. All bars = 200 μm