Fig. 9

Fance deficient PGCs down-regulated the BER pathway during rapid mitosis. (A) Representative images of co-localized staining of NEIL2 and SSEA1 in Fance^−/− PGCs and Fance^+/+ PGCs. (B) The proportion of NEIL2 positive cells was significantly decreased in Fance^−/− PGCs compared to Fance^+/+ PGCs. (C) Representative images of co-localized staining of PARP3 and SSEA1 in Fance^−/− PGCs and Fance^+/+ PGCs. (D) There was no significant difference in the proportion of PARP3 positive PGCs between Fance^−/− and Fance^+/+ mice at E11.5 and E12.5. n = 4 embryos. All bars = 200 μm