Does the addition of metformin to carboplatin treatment decreases ovarian reserve damage associated with carboplatin usage?

Table 3 Distributions of tissue catalase and malondialdehyde levels between groups

	Group 1 (Sham)	Grup2 (CP + Saline)	Group 3 (CP + Mtf)	Group 4 (Mtf)	Group 5 (Saline)	^*p
Catalase	32.7 ± 2.7^a	23.3 ± 5.1^a,b,c,d	27.9 ± 2.2^b	33.9 ± 4.0^c	34.7 ± 5.4^d	< 0.001
Malondialdehyde	87.8 ± 17.1^e	146.7 ± 23.8^e,f,g,h	93.9 ± 21.9^f	96.7 ± 26.5^g	86.9 ± 13.2^h	< 0.001

Note.^*p = Kruskal–Wallis test. (a) difference in catalase between Group 1 and Group 2, p < 0.001; (b) difference in catalase between Group 2 and Group 3, p < 0.05; (c) difference in catalase between Group 2 and Group 4, p < 0.001; (d) difference in catalase between Group 2 and Group 5, p < 0.001; (e) difference in malondialdehyde between Group 1 and Group 2, p < 0.001; (f) difference in malondialdehyde between Group 2 and Group 3, p < 0.001; (g) difference in malondialdehyde between Group 2 and Group 4, p < 0.001; (h) difference in malondialdehyde between Group 2 and Group 5, p < 0.001

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