Fig. 5

Silencing of PAPSS1 improves in vivo sensitivity to cisplatin. A, B Representative H&E and IHC staining of PAPSS1 in different groups. Scale bar: 100 µm. C, D The volume and ki67 expression of the ovarian tumor xenograft derived from sh-PAPSS1 transfected A2780 and SKOV3 cells were significantly lower than those derived from shSCR transfected A2780 and SKOV3 cells. Scale bar: 50 µm. Data are shown as mean ± SE. N vs. PBS and shSCR + PBS, P > 0.05; * vs. PBS and shSCR + PBS, P < 0.05; ** vs. PBS and shSCR + PBS, P < 0.01; ^# vs. PBS and shSCR + PBS, P < 0.001