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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency

Fig. 5

The verification of hub genes by qRT‒PCR. The identified ten hub genes were downregulated significantly in human granulosa cells from bPOI patients compared to control patients (n = 12 in each group, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, Mann–Whitney U-test). bPOI: biochemical premature ovarian insufficiency; CON: control; UBE2C: ubiquitin conjugating enzyme E2 C; PBK: PDZ binding kinase; BUB1: BUB1 mitotic checkpoint serine/threonine kinase; CDC20: cell division cycle 20; CENPA: centromere protein A; NUSAP1: nucleolar and spindle associated protein 1; CCNB2: cyclin B2; TOP2A: DNA topoisomerase II alpha; AURKB: aurora kinase B; FOXM1: forkhead box M1

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Journal of Ovarian Research

ISSN: 1757-2215

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