Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency

Table 1 Clinical characteristics of bPOI patients and control patients for RNAseq

Variable	bPOI (n = 6)	CON (n = 5)	P
Age(years)	32.333 ± 2.338	31.200 ± 1.789	0.399
BMI (kg/m²)	20.967 ± 2.749	20.440 ± 1.595	0.702
Basal FSH (IU/L)	17.348 ± 5.242	6.122 ± 0.816	0.001
Basal LH (IU/L)	6.242 ± 2.172	5.814 ± 2.132	0.751
AMH (ng/ml)	0.598 ± 0.197	3.328 ± 0.993	< 0.001
Basal E₂ (pg/ml)	28.228 ± 8.847	33.298 ± 6.611	0.319
Bilateral AFC	6.000 ± 2.366	13.600 ± 2.302	< 0.001
Number of follicles over 14 mm on HCG Day	3.500 ± 1.643	11.200 ± 5.167	0.007
Number of oocytes obtained	2.670 ± 1.366	13.400 ± 5.320	0.009

Data are presented as mean ± SEM based on distribution, Student’s t-test
bPOI Biochemical premature ovarian insufficiency, BMI Body mass index, FSH Follicle-stimulating hormone, LH Luteinizing hormone, AMH Anti-Mullerian hormone, E₂ Estradiol, AFC Antral follicle counts, HCG Human chorionic gonadotropin

ISSN: 1757-2215