Fig. 3

Specific energy supply during EMT. A Developmental trajectory of cells in two dimensions. Cells are coloured according to cell type (left), state (middle), and pseudotime (right). The red arrows indicate the defined "epithelial-mesenchymal path". B The number of cells per cell type in each developmental state. C Variations in EMT pathway activity with pseudotime. D-F The pathway activity of OXPHOS, glycolytic and hypoxic distribution with pseudotime. G The heatmap shows the branch-dependent genes at branch point 1. The centre of the heatmap indicates branch B1, the left indicates branch B2, and the right indicates branch B3. H The invasive activity distribution with pseudotime. I The stem activity distribution with pseudotime. J Bar graphs reflect the Pearson correlation between OXPHOS, glycolysis and hypoxia pathway activity and EMT, invasion and stemness pathway activity. The height of the bar reflects the correlation coefficient, and the number of * reflects P-value. K-L Enrichment of up- and downregulated genes associated with pseudotime in the GO term