Fig. 6

Suppressed EGR1 Decreases Expression of FAS and HSPG2. A-D A positive correlation was observed between EGR1 and its targets FAS and HSPG2 in the GSE118828 and TCGA datasets. E-F The FAS and HSPG2 expression levels were positively correlated with EMT activity. G-H Enriched EGR1 sequencing read peaks were found in the FAS and HSPG2 transcription factor binding regions. I-J The protein expression levels of FAS and HSPG2 were markedly downregulated in the EGR1-si group in SKOV3 and A2780 cells