Table 1 Summary Results of MR (Target Systemic inflammatory regulators on POI)
Exposure | Method | NSNPs | OR(95% CI) | P | Cochran Q-test | Directional pleiotropy | Correct Causal direction | ||
|---|---|---|---|---|---|---|---|---|---|
P | I2 (%) | Egger intercept (P) | MRPRESSO global test RSSobs (P) | ||||||
VEGF | IVW | 10 | 0.73(0.54–0.99) | 4.60E-02 | 0.516 | 0.00 | -0.020(0.759) | 8.788(0.688) | TRUE |
VEGF | cML-MA-BIC | 10 | 0.73(0.53-1.00) | 4.80E-02 | Â | Â | Â | Â | Â |
VEGF | Maximum likelihood | 10 | 0.73(0.53–0.99) | 4.60E-02 |  |  |  |  |  |
VEGF | MR Egger | 10 | 0.78(0.46–1.31) | 0.38 |  |  |  |  |  |
VEGF | Weighted median | 10 | 0.73(0.52–1.03) | 0.07 |  |  |  |  |  |
IL-10 (before eliminating) | IVW | 10 | 0.53(0.33–0.85) | 9.10E-03 | 0.392 | 5.33 | -0.026(0.729) | 10.707(0.520) | TRUE |
IL-10 (before eliminating) | cML-MA-BIC | 10 | 0.52(0.32–0.84) | 7.10E-03 |  |  |  |  |  |
IL-10 (before eliminating) | Maximum likelihood | 10 | 0.53(0.33–0.84) | 7.40E-03 |  |  |  |  |  |
IL-10 (before eliminating) | MR Egger | 10 | 0.63(0.22–1.78) | 0.41 |  |  |  |  |  |
IL-10 (before eliminating) | Weighted median | 10 | 0.52(0.30–0.91) | 2.30E-02 |  |  |  |  |  |
IL-10 (after eliminating) | IVW | 9 | 0.54 (0.33–0.88) | 2.10E-02 | 0.723 | 0.00 | -0.017(0.079) | 10.346(0.453) | TRUE |
IL-10 (after eliminating) | cML-MA-BIC | 9 | 0.55 (0.33–0.91) | 1.30E-02 |  |  |  |  |  |
IL-10 (after eliminating) | Maximum likelihood | 9 | 0.54 (0.33–0.88) | 1.30E-02 |  |  |  |  |  |
IL-10 (after eliminating) | MR Egger | 9 | 0.61 (0.20–1.86) | 0.41 |  |  |  |  |  |
IL-10( after eliminating) | Weighted median | 9 | 0.53 (0.30–0.93) | 2.80E-02 |  |  |  |  |  |