Fig. 3

Estimation and validation of the prognostic signature based on the six pyroptosis-related genes (PRGs). The distribution of the risk score, survival time (months), and survival status of ovarian cancer (OV) patients in the TCGA training set (A) and the ICGC validation set (B). The scatter diagrams represented the risk score of different OV patients, refer to corresponding survival time and survival status (top and middle). The heatmaps (bottom) showed gene expression of the 6-gene signature between low-risk and high-risk groups. The Kaplan-Meier (K-M) curves for overall survival (OS), classified into the low-risk and high-risk groups of the TCGA training set (C) and the ICGC validation set (D). The ROC analysis of the TCGA training set (E) and the ICGC validation set (F) of OS prediction by the 6-gene signature based on PRGs.