Table 4 Subgroup analysis of FET Outcomes with or without GnRHa

Age (years)

Type of infertility

 < 40

 ≥ 40

Primary

Secondary

GnRHa (N = 556)

Without GnRHa (N = 999)

p

GnRHa (N = 74)

Without GnRHa (N = 142)

p

GnRHa (N = 310)

Without GnRHa (N = 516)

p

GnRHa (N = 320)

Without GnRHa (N = 625)

p

Age (years)

30.8 ± 4.1

31.0 ± 4.0

0.426

41.5 ± 1.5

41.9 ± 1.6

0.14

30.2 ± 4.4

30.5 ± 4.4

0.318

33.8 ± 5.3

33.8 ± 5.4

0.932

Number of transferred embryos

1.7 ± 0.4

1.7 ± 0.4

0.881

1.6 ± 0.4

1.6 ± 0.4

0.426

1.7 ± 0.4

1.7 ± 0.4

0.856

1.7 ± 0.4

1.7 ± 0.4

0.856

Grade of transferred embryos^a(%)

0.352

0.836

0.286

0.958

 Cleavage I

116/556 (20.9)

239/999 (23.9)

22 (29.7)

37 (26.1)

63/310 (20.3)

125/516 (24.2)

75/320 (23.4)

151/625 (24.2)

 Cleavage II

252/556 (45.3)

445/999 (44.5)

47 (63.5)

94 (66.2)

144/310 (46.5)

242/516 (46.9)

155/320 (48.4)

297/625 (47.5)

 Blastocyst

188/556 (33.8)

315/999 (31.5)

5 (6.8)

11 (7.7)

103/310 (33.2)

149/516 (28.9)

90/320 (28.1)

177/625 (28.3)

Endometrial thickness (mm)

9.4 ± 1.5

9.3 ± 1.5

0.193

9.0 ± 1.4

9.0 ± 1.3

0.935

9.5 ± 1.5

9.4 ± 1.4

0.498

9.2 ± 1.5

9.1 ± 1.5

0.400

Triple- line Endometrium (%)

531 (95.5)

893 (89.4)

0.000

66 (89.2)

129 (90.8)

0.697

296/310 (95.5)

472/516 (91.5)

0.029

301/320 (94.1)

550/625 (88.0)

0.003

Biochemical pregnancy rate (%)

354/556 (63.7)

575/999 (58.6)

0.019

28 (37.8)

44 (31)

0.311

210/310 (67.7)

315/516 (61.0)

0.053

172/320 (53.8)

304/625 (48.6)

0.137

Implantation rate (%)

371/972 (38.1)

564/1743 (32.3)

0.002

19/121 (15.7)

27/240 (11.2)

0.231

230/548 (42.0)

305/915 (33.3)

0.000

160/545 (29.4)

286/1068 (26.8)

0.273

Clinical pregnancy rate (%)

297 (53.4)

466 (46.6)

0.01

17 (23)

28 (19.7)

0.576

180/310 (58.1)

251/516 (48.6)

0.009

134/320 (41.9)

243/625 (38.9)

0.374

Ectopic pregnancy (%)

8 (1.4)

16 (1.6)

0.803

0

1 (0.7)

1.000

5/310 (1.6)

6/516 (1.2)

0.585

3/320 (0.9)

11/625 (1.8)

0.322

Early miscarriage (%)

32 (5.8)

53 (5.3)

0.708

5 (6.8)

12 (8.5)

0.661

17/310(5.5)

34/516 (6.6)

0.523

20 (6.3)

31 (5.0)

0.406

Live birth (%)

236 (42.4)

370(37)

0.036

12 (16.2)

14 (9.9)

0.173

148(47.7)

197(38.2)

0.007

100(31.3)

187(29.9)

0.674

PCOS

Menstruation^b

Yes

No

Regular

Irregular

GnRHa (N = 111)

Without GnRHa (N = 238)

p

GnRHa (N = 519)

Without GnRHa (N = 903)

p

GnRHa (N = 397)

Without GnRHa (N = 638)

p

GnRHa (N = 207)

Without GnRHa (N = 453)

p

Age(years)

29.8 ± 3.9

29.7 ± 4.0

0.801

32.5 ± 5.3

33 ± 5.3

0.098

33.0 ± 5.3

33.4 ± 5.5

0.213

30.1 ± 4.3

30.7 ± 4.3

0.156

Number of transferred embryos

1.7 ± 0.4

1.7 ± 0.4

0.574

1.7 ± 0.4

1.7 ± 0.4

0.725

1.7 ± 0.4

1.7 ± 0.4

0.480

1.7 ± 0.4

1.7 ± 0.4

0.584

Grade of transferred embryos^a

0.613

0.543

0.294

0.943

 Cleavage I

21 (18.9)

51 (21.4)

117 (22.5)

225 (24.9)

92 (23.2)

170 (26.6)

43 (20.8)

93 (20.5)

 Cleavage II

40/ (36.0)

93 (39.1)

259 (49.9)

446 (49.4)

194 (48.9)

313 (49.1)

89 (43.0)

201 (44.4)

 Blastocyst

50 (45.0)

94 (39.5)

143 (27.6)

232 (25.7)

111 (28.0)

155 (24.3)

75 (36.2)

159 (35.1)

Endometrial thickness (mm)

9.1 ± 1.4

9.1 ± 1.5

0.873

9.4 ± 1.5

9.3 ± 1.4

0.18

9.5 ± 1.6

9.3 ± 1.4

0.125

9.1 ± 1.3

9.2 ± 1.4

0.52

 Triple- line Endometrium (%)

108 (97.3)

213 (89.5)

0.012

489 (94.2)

809 (89.6)

0.003

371 (93.5)

579 (90.8)

0.124

203 (98.1)

398 (87.9)

0.000

 Biochemical pregnancy rate (%)

92 (82.9)

149 (62.6)

0.000

290 (55.9)

470 (52)

0.164

215 (54.2)

322 (50.5)

0.248

151 (72.9)

270 (59.6)

0.001

 Implantation rate (%)

102/198 (51.5)

156/418 (37.3)

0.000

288/895 (32.1)

435/1565 (27.7)

0.021

211/684 (30.8)

292/1112 (26.25)

0.035

164/362 (45.3)

218/783 (27.8)

0.000

 Clinical pregnancy rate (%)

77 (69.4)

127 (53.4)

0.005

237 (45.7)

367 (40.6)

0.065

173 (43.6)

250 (39.2)

0.162

127 (61.4)

222 (49)

0.003

 Ectopic pregnancy rate (%)

1 (0.9)

5 (2.1)

0.669

7 (1.3)

12 (1.3)

0.975

4 (1.0)

9 (1.4)

0.802

3 (1.4)

6 (1.3)

1.00

 Early miscarriage (%)

7 (6.3)

15 (6.3)

0.541

30 (5.8)

50 (5.5)

0.848

19 (4.8)

40 (6.3)

0.317

16 (7.7)

23 (5.1)

0.18

 Live birth (%)

65 (58.6)

99 (41.6)

0.003

183 (35.3)

285 (31.6)

0.153

137 (34.5)

187 (29.3)

0.079

100 (48.3)

180 (39.7)

0.039