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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model

Fig. 4

hUC-MSCs activated PI3K/AKT/mTOR pathway by mediating VEGF in the ovary; scale bar: 100 μm. A The localization of PKH26 labeled hUC-MSCs in the POF ovary after transplanting for 2, 7, and 14 days. B The human ALU gene levels in rat ovary after hUC-MSCs transplanting for 2, 7, and 14 days. C VEGF levels in serum after hUC-MSCs transplanting for two days. D The biological process of GO enrichment involved in VEGF regulating oxidative stress. E The signaling pathways of differential proteins enrichment after MSCs transplantation. F VEGF and PI3K/AKT/mTOR-related protein expressions in ovaries after MSCs transplantation. VEGFA (G) and VEGFB (H) expressions were determined in ovaries using immunohistochemistry; scale bar: 500 μm and 200 μm. I The quantification of VEGFA and VEGFB expression in G and H, respectively. *p < 0.05. **p < 0.01

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Journal of Ovarian Research

ISSN: 1757-2215

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