Table 1 Baseline and cycle characteristics of the GH and control groups before/after propensity score matching
Before PSM | After PSM | |||||
|---|---|---|---|---|---|---|
GH group N = 143 | Control group N = 549 | P-value | GH group N = 140 | Control group N = 272 | P-value | |
Baseline characteristics | ||||||
Age (years) | 41.30 ± 2.31 | 41.13 ± 2.07 | 0.38 | 41.25 ± 2.31 | 41.20 ± 2.05 | 0.83 |
Age distribution, n (%) | ||||||
38–40 years | 63 (44.06) | 243 (44.26) | 0.125 | 63 (45.00) | 117 (43.00) | 0.38 |
41–43 years | 50 (34.97) | 226 (41.17) | 49 (35.00) | 112 (41.20) | ||
44–46 years | 30 (20.97) | 80 (14.57) | 28 (20.00) | 43 (15.80) | ||
BMI (kg/m2) | 21.72 ± 2.41 | 21.97 ± 2.66 | 0.31 | 21.74 ± 2.43 | 21.68 ± 2.38 | 0.83 |
No. of previous OS cycles | 3.16 ± 2.00 | 2.55 ± 1.79 | 0.00 | 3.06 ± 1.89 | 2.97 ± 1.99 | 0.66 |
Indication for PGT-A, n (%) | ||||||
AMA | 22 (15.39) | 129 (23.50) | 0.09 | 22 (15.70) | 45 (16.50) | 0.71 |
AMA with history of PL due to aneuploidy | 51 (35.66) | 206 (37.52) | 51 (36.40) | 88 (32.40) | ||
AMA with RIF | 33 (23.08) | 94 (17.12) | 33 (23.60) | 67 (24.60) | ||
AMA with RPL | 37 (25.87) | 120 (21.86) | 34 (24.30) | 72 (26.50) | ||
Ovarian reserve | ||||||
Basal FSH (mIU/mL) | 9.99 ± 4.85 | 10.09 ± 4.90 | 0.83 | 9.95 ± 4.85 | 10.00 ± 4.22 | 0.92 |
Basal LH (mIU/mL) | 4.75 ± 2.58 | 4.50 ± 2.30 | 0.26 | 4.76 ± 2.60 | 4.46 ± 2.67 | 0.22 |
Basal E2 (pg/ml) | 45.87 ± 19.90 | 42.44 ± 21.94 | 0.09 | 45.60 ± 20.00 | 44.63 ± 23.15 | 0.67 |
AMH (ng/mL) | 1.54 ± 1.53 | 1.70 ± 1.41 | 0.23 | 1.56 ± 1.54 | 1.55 ± 1.01 | 0.93 |
AFC | 8.32 ± 5.33 | 8.85 ± 6.08 | 0.35 | 8.39 ± 5.36 | 8.41 ± 5.66 | 0.96 |
Cycle characteristics | ||||||
Duration of stimulation (days) | 9.36 ± 1.83 | 9.16 ± 2.75 | 0.41 | 9.41 ± 1.80 | 9.37 ± 2.79 | 0.87 |
Total dosage of gonadotropins (ampoules, 75 IU/ampoule) | 34.57 ± 12.25 | 32.09 ± 16.11 | 0.09 | 34.66 ± 12.36 | 34.17 ± 16.94 | 0.77 |
Oestradiol on trigger day (pg/ml) | 2637.05 ± 1847.10 | 2844.30 ± 1911.75 | 0.25 | 2657.15 ± 1860.78 | 2779.61 ± 1900.54 | 0.53 |
No. of oocytes retrieved | 6.97 ± 4.94 | 7.67 ± 5.51 | 0.17 | 7.06 ± 4.95 | 7.42 ± 5.20 | 0.50 |
No. of mature oocytes (MII) retrieved | 5.52 ± 3.84 | 6.19 ± 4.53 | 0.11 | 5.59 ± 3.85 | 6.08 ± 4.45 | 0.27 |
Fertilized oocytes (2PN) | 4.62 ± 3.60 | 5.25 ± 3.97 | 0.09 | 4.69 ± 3.61 | 5.21 ± 4.01 | 0.20 |
No. of cleavage stage embryos | 3.50 ± 2.92 | 3.97 ± 3.27 | 0.12 | 3.54 ± 2.94 | 3.88 ± 2.36 | 0.30 |
No. of high-quality embryos on day 3 | 2.70 ± 2.58 | 3.03 ± 2.73 | 0.20 | 2.74 ± 2.59 | 2.96 ± 2.70 | 0.43 |
No. of blastocysts | 1.64 ± 1.68 | 1.87 ± 1.89 | 0.18 | 1.65 ± 1.69 | 1.81 ± 1.93 | 0.40 |