Growth hormone supplementation during ovarian stimulation in women with advanced maternal age undergoing preimplantation genetic testing for Aneuploidy

Table 4 Logistic regression analyses of variables associated with the acquisition of euploid embryos*

Variables	P-value	Adjusted OR	95%CI
Women aged 38–46 years
GH supplement	0.001	2.273	1.381–3.745
Age	0.000	0.637	0.561–0.723
AFC	0.000	1.113	1.064–1.164
Subgroup- Women aged 38–40 years
GH supplement	0.006	2.653	1.318–5.348
AFC	0.000	1.194	1.106–1.288
Subgroup-Women aged 41–43 years
Age	0.032	0.591	0.365–0.956
AMH	0.022	1.587	1.068–2.360

*Confounders including GH supplement, age, AMH, AFC, BMI, number of previous OS cycles, duration of stimulation, total dosage of gonadotropins, and estradiol on trigger day, were evaluated using multivariate logistic regression models (backward LR). Covariates were retained in the final adjusted model if they were significantly associated with the outcome parameters (P < 0.05). For the subgroup of women aged 44–46 years, none of the aforementioned variables were significantly associated with the acquisition of euploid embryos; therefore, they are not presented in the table. GH = growth hormone; OR = odds ratio; CI = Confidence interval; AFC = antral follicle count; BMI = body mass index; AMH = anti-Mullerian hormone; OS = ovarian stimulation

ISSN: 1757-2215