Fig. 1
From: Rare variants in GPR3 in POI patients: a case series with review of literature
Identification of GPR3 variants in two POI patients. A Sanger sequencing confirmed the heterozygous GPR3 variants in patients. The red arrows indicate the positions of the two variants. B The amino acid residues of GPR3 corresponding to the identified variants are conserved across species. The red arrows indicate the positions of the affected residues. C Overview of the predicted structure of GPR3 protein. The enlarged boxes indicate the locations of the affected residues