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Table 2 Differences in the number of samples with specific mutations between the two pathological subtypes

From: Deciphering tumor immune microenvironment differences between high-grade serous and endometrioid ovarian cancer to investigate their potential in indicating immunotherapy response

Gene

HGSOC (n = 43)

EEOC (n = 9)

P-value

Effect size

TP53

33 (76.74%)

6 (66.67%)

0.6739

1.00

TTN

13 (30.23%)

1 (11.11%)

0.4147

1.00

MUC4

8 (18.60%)

1 (11.11%)

> 0.9999

1.00

OBSCN

6 (13.95%)

3 (33.33%)

0.1767

1.00

OR1S1

7 (16.28%)

1 (11.11%)

> 0.9999

1.00

RYR2

6 (13.95%)

1 (11.11%)

> 0.9999

1.00

ABCC5

5 (11.63%)

1 (11.11%)

> 0.9999

1.00

MYO18B

7 (16.28%)

0 (0.00%)

0.3309

1.00

PDE4DIP

6 (13.95%)

1 (11.11%)

> 0.9999

1.00

PKHD1

4 (9.30%)

3 (33.33%)

0.0900

1.00

SYNE1

4 (9.30%)

3 (33.33%)

0.0900

1.00

ZNF536

6 (13.95%)

0 (0.00%)

0.5745

1.00

ZNF831

5 (11.63%)

1 (11.11%)

> 0.9999

1.00

CRIPAK

6 (13.95%)

0 (0.00%)

0.5745

1.00

DYNC1H1

5 (11.63%)

1 (11.11%)

> 0.9999

1.00

KMT2C

4 (9.30%)

2 (22.22%)

0.2750

1.00

PLXNB2

6 (13.95%)

0 (0.00%)

0.5745

1.00

RGS12

6 (13.95%)

0 (0.00%)

0.5745

1.00

TAF1L

4 (9.30%)

2 (22.22%)

0.2750

1.00

  1. Footnote: HGSOC, high-grade serous ovarian cancer. EEOC, endometrioid epithelial ovarian cancer. Statistics: Fisher’s exact test