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Fig. 3 | Journal of Ovarian Research

Fig. 3

From: The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial

Fig. 3

Intestinal permeability led to leakage of LPS intothe systemic circulation and stimulated the immune response and neuro-inflammation, which further increase the BBB permeability and deregulation in serum levels of S100B; also neuro-inflammation was able to alter the BDNF levels, which may have caused disorders in follicular growth. By interfering with LPS leakage and antioxidant properties, thylakoids may have impaired this series of disorders in PCOS patients

Abbreviations: BBB: blood-brain barrier; BDNF: brain-derived neurotrophic factor; LPS: lipopolysaccharides; NF-κB: nuclear factor kappa B; ROS: reactive oxygen species; S100B: S100 calcium-binding protein B

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Journal of Ovarian Research

ISSN: 1757-2215

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