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Table 2 Oxidative stress markers in the FF of patients with DOR and NOR

From: Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization

 

Control

DOR

P

P adjusted

rGSH (µmol/L)#

5.81(3.48–7.22)

4.65(2.86–6.63)

0.117

0.178

T-GSH (µmol/L)#

10.84(9.63–12.53)

9.90(9.63–12.01)

0.041*

0.030*

GSSG (µmol/L)#

rGSH/GSSG&

GSH-PX (U/mL)&

SOD (U/mL)#

POD (U/mL)#

CAT (U/mL)&

TAOC (U/mL)#

MDA (nmol/mL)#

LPO (µmol/L)#

4.69(4.64–6.57)

1.21 ± 0.90

148.97 ± 39.34

31.28(30.50-32.74)

7.93(7.03–9.05)

3.14 ± 1.22

0.97(0.88–1.04)

2.12(1.63–2.79)

40.72(34.43–44.59)

4.69(4.63–5.63)

1.02 ± 0.52

141.07 ± 50.15

31.57(29.55–32.97)

8.33(6.46–10.16)

3.08 ± 0.97

1.00(0.91–1.09)

2.19(1.52–2.63)

40.72(36.82-46.00)

0.888

0.208

0.390

0.996

0.672

0.455

0.366

0.668

0.932

0.349

0.380

0.554

0.659

0.164

0.454

0.568

0.856

0.298

Protein Carbonylation (nmol/mgprot)#

0.53(0.23–0.81)

0.56(0.34–0.86)

0.227

0.325

8-OHdG (ng/mL)#

57.49(32.18–78.95)

55.23 (35.16–82.52)

0.156

0.316

  1. rGSH, reduced glutathione; T-GSH, total glutathione; GSSG, oxidized glutathione; GSH-PX, Glutathione peroxidase; SOD, superoxide dismutase; POD, peroxidase; CAT, catalase; TAOC, total antioxidant capacity; MDA, malondialdehyde; LPO, lipid peroxidation; 8-OHdG, 8-Hydroxy-2’-deoxyguanosine.
  2. *Difference is considered significant.
  3. &Values are presented as the mean ± SD for continuous indicators following normal distribution. Student’s t-test for continuous variables
  4. # Values are presented as the median (interquartile range) for continuous indicators not following normal distribution. Mann–Whitney U test for categorical variables\
  5. P adjusted: age and dosage of FSH for ovarian stimulation are adjusted as covariants.