Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization

Table 3 Inflammatory factors in the FF of patients with DOR and NOR

	Control	DOR	P	P adjusted
IL-6 (pg/mL)^#	1.89 (0.79–5.25)	1.89(0.91–8.41)	0.528	0.414
IL-18 (pg/mL)^#	25.47(4.33–50.71)	10.65(3.86–24.71)	0.013*	0.05*
TNF-α (pg/mL)^# IL-1β (pg/mL)^# hs-CRP (ng/mL)^# IL-10 (pg/mL)^# IL-2 (pg/mL)^# IL-15 (pg/mL)^&	58.92(41.95–81.59) 1.29(0.75–4.08) 744.68(289.69-1498.96) 3.32(1.79–5.04) 5.99(3.12–11.70) 3.91 ± 2.96	92.24(64.30-126.60) 1.84(1.04–5.64) 689.04(232.28-1218.75) 4.13(1.40-12.94) 4.46(2.96–10.77) 4.28 ± 3.19	0.000* 0.298 0.650 0.258 0.236 0.568	0.003* 0.359 0.060 0.069 0.929 0.551

IL-6, interleukin 6; IL-18, interleukin 18; TNF-α, tumor necrosis factor α; IL-1β interleukin 1β; hs-CRP, high-sensitivity C-reactive protein; IL-10, interleukin 10; IL-2, interleukin 2; IL-15, interleukin 15; IL-8, interleukin 8.
*Difference is considered significant.
^&Values are presented as the mean ± SD for continuous indicators following normal distribution. Student’s t-test for continuous variables
^# Values are presented as the median (interquartile range) for continuous indicators not following normal distribution. Mann–Whitney U test for categorical variables
P adjusted: age and dosage of FSH for ovarian stimulation are adjusted as covariants.

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