Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline

Table 2 The clinical features and AR CAG frequency distribution of controls, L-AFC and H-AFC PCOS cases

Variable		Control (n = 61)	L-AFC (n = 92)	H-AFC (n = 17)	p value^a (overall)	p value^b (L-AFC vs H-AFC)
Baseline
Age (years)		29.52 ± 4.43	27.68 ± 4.61	27.06 ± 2.86	0.021	0.591
BMI (kg/m²)		23.15 ± 3.57	25.11 ± 3.98	26.45 ± 5.25	0.002	0.205
LH (IU/L)		3.57 ± 1.67	9.86 ± 6.29	10.71 ± 5.80	< 0.001	0.547
FSH (IU/L)		5.93 ± 2.19	5.87 ± 1.53	5.79 ± 2.26	0.965	0.868
E₂ (pg/mL)		46.69 ± 24.30	54.72 ± 37.07	62.73 ± 43.01	0.854	0.207
TT (ng/dL)		41.76 ± 15.94	67.07 ± 36.29	60.55 ± 24.88	< 0.001	0.607
AR CAG frequency distribution*
Short allele	< 21	17(27.87%)	31(33.70%)	9(52.94%)	0.153	0.130
Short allele	≥ 21	44(72.13%)	61(66.30%)	8(47.06%)	-	-
Long allele	< 24	24(39.34%)	30(32.61%)	10(58.82%)	0.115	0.039
Long allele	≥ 24	37(60.66%)	62(67.39%)	7(41.18%)	-	-
Biallelic average	< 22.5	20(32.79%)	35(38.04%)	11(64.71%)	0.056	0.041
Biallelic average	≥ 22.5	41(67.21%)	57(61.96%)	6(35.29%)	-	-

All values were reported as mean ± SD and number (percent)
Abbreviations: PCOS polycystic ovary syndrome, AFC antral follicle count, BMI body mass index, LH luteinizing hormone, FSH follicle stimulating hormone, E2 estradiol, TT total testosterone, AR androgen receptor, L-AFC low AFC (AFC < 20), H-AFC high AFC (AFC ≥ 20)
^*Represents the median CAG repeats length of all cases including controls and PCOS
^aP value was given by the one-factor analysis of variance and chi-square test among three groups
^bP value was given by the post-hoc analysis of least significance difference and chi-square test between L-AFC and H-AFC groups

ISSN: 1757-2215