Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes

Table 2 Summary of reproductive phenotypes of the mice at 2 or 4 weeks after PCOS models were established

	Continue dosing group				Stop dosing group
	DHEA		DHEA + HFD		DHEA		DHEA + HFD
	2 weeks	4 weeks	2 weeks	4 weeks	2 weeks	4 weeks	2 weeks	4 weeks
Disturbed estrous cycle	^a✓	✓	✓	✓	×	×	×	×
Hyperandrogenemia	✓	✓	✓	✓	×	×	×	×
Polycystic ovaries	✓	✓	✓	✓	-	×	-	×
Maintain PCOS reproductive phenotypes	✓	✓	✓	✓	×	×	×	×

ISSN: 1757-2215