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Fig. 7 | Journal of Ovarian Research

Fig. 7

From: Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis

Fig. 7

Illustrations Depicting Investigated Associations in the Study. A Estimation of the total effect of PCOS on BC, β, through two-sample MR. B Decomposition of the total effect into: (i) indirect effect, calculated using a two-step approach, in which β1 represents the total effect of PCOS on BC and β2 represents the effect of age at menopause on BC while adjusting for PCOS. (ii) direct effect (β’ = β-β1 × β2). Mediation effects were obtained by dividing the indirect effect (β1 × β2) by the total effect (β)

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Journal of Ovarian Research

ISSN: 1757-2215

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