Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis

Table 1 Details of SNPs selected as exposure IVs

RSID	Effect Allele	Other Allele	EAF	beta	OR	se	p-Value	R ²	F
rs7563201	G	A	0.451	-0.108	0.900	0.017	3.68E-10	0.002	39.422
rs2178575	A	G	0.151	0.166	1.180	0.022	3.34E-14	0.003	57.448
rs13164856	T	C	0.729	0.124	1.130	0.019	1.45E-10	0.002	41.274
rs804279	T	A	0.262	0.128	1.140	0.018	3.76E-12	0.003	48.388
rs10739076	A	C	0.308	0.110	1.120	0.020	2.51E-08	0.002	31.175
rs7864171	A	G	0.428	-0.093	0.910	0.017	2.95E-08	0.002	30.641
rs9696009	A	G	0.068	0.202	1.220	0.031	7.96E-11	0.002	42.182
rs11031005	T	C	0.854	-0.159	0.850	0.022	8.66E-13	0.003	50.832
rs11225154	A	G	0.094	0.179	1.200	0.027	5.44E-11	0.003	43.303
rs1784692	A	G	0.824	0.144	1.150	0.023	1.88E-10	0.002	40.594
rs2271194	T	A	0.416	0.097	1.100	0.017	4.57E-09	0.002	34.141
rs1795379	T	C	0.24	-0.117	0.890	0.020	1.81E-09	0.002	35.996
rs8043701	A	T	0.815	-0.127	0.880	0.021	9.61E-10	0.002	37.276
rs853854	T	A	0.499	-0.098	0.910	0.016	2.36E-09	0.002	36.143

SNP is considered to be of adequate instrument strength with F statistics > 10. R ² is the degree to which IV explains exposure (determinant of regression equation). EAF effect allele frequency

ISSN: 1757-2215