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Table 2 Details of GWASs included in MR analyses

From: Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis

Trait

Consortium

Ethnicity

Sample Size

GWAS ID

SHBG (adjusted for BMI)

EBI

European

368929

ebi-a-GCST90012110

Bioavailable testosterone levels

EBI

European

382988

ebi-a-GCST90012104

Total testosterone levels

EBI

European

425097

ebi-a-GCST90012114

Estrogen Receptor

pQTL

European

3301

prot-a-991

AMH

NA

European

7049

GCST90104596

Female Infertility

FinnGen Biobank

European

75450

finn-b-N14-FEMALEINFERT

Infertility (associated with anovulation)

FinnGen Biobank

European

118152

finn-b-N14-FIANOV

Age at Menarche

ReproGen

European

182416

ieu-a-1095

Age at menopause

ReproGen

European

69360

ieu-a-1004

IGF-1

MRC-IEU

European

468262

ukb-d-30770_irnt

HOMA-IR

MAGIC

European

37037

ieu-b-118

Triglycerides

EBI

European

94595

ebi-a-GCST002216

Type 2 diabetes

EBI

European

655666

ebi-a-GCST006867

BC(Combined Oncoarray; iCOGS; GWAS meta analysis)

BCAC

European

228951

ieu-a-1126

ER + BC(Combined Oncoarray; iCOGS; GWAS meta analysis)

BCAC

European

175475

ieu-a-1127

ER- BC(Combined Oncoarray; iCOGS; GWAS meta analysis)

BCAC

European

127442

ieu-a-1128

  1. EBI European Bioinformatics Institute, pQTL Protein Quantitative Trait Loci Consortium, MRC-IEU Medical Research Council Integrative Epidemiology Unit, FinnGen Biobank Finnish National Genome Center Biobank, ReproGen Reproductive Genetics, Epigenetics & Development Group, MAGIC Meta-Analyses of Glucose and Insulin-related traits Consortium, BCAC Breast Cancer Association Consortium, NA not available