Table 3 MVMR analysis of the exposure and mediators on outcome
Exposure/Outcome | Adjusted factors | Multivariate MR analysis | Mediation effects(%) | |||||
|---|---|---|---|---|---|---|---|---|
Raw estimates | Outliers corrected estimates | |||||||
N | Beta | p -Value | N | Beta | p -Value | |||
PCOS/BC | Age at Menopause | 6 | -0.054 | 0.092 | 5 | -0.005 | 0.683 | |
PCOS/ER + BC | 6 | -0.009 | 0.022 | NA | NA | NA | -4.820 | |
PCOS/ER- BC | 6 | -0.004 | 0.910 | NA | NA | NA | ||
PCOS/BC | IGF-1 | 530 | -0.008 | 0.409 | 501 | -0.006 | 0.432 | |
PCOS/ER + BC | 530 | -0.005 | 0.630 | 505 | -0.007 | 0.420 | ||
PCOS/ER- BC | 530 | -0.007 | 0.326 | 522 | -0.011 | 0.371 | ||
PCOS/BC | Triglycerides | 44 | -0.009 | 0.768 | 40 | -0.019 | 0.470 | |
PCOS/ER + BC | 44 | -0.030 | 0.398 | 38 | -0.048 | 0.095 | ||
PCOS/ER- BC | 44 | -0.046 | 0.360 | NA | NA | NA | ||