Table 4 Heterogeneity and pleiotropy analysis
Exposure | Outcome | Heterogenity | Pleiotropy | |||
|---|---|---|---|---|---|---|
Method | Cochran’s Q | p -Value | Egger-Intercept | p -Value | ||
PCOS | Bioavailable testosterone levels | IVW | 52.663 | 2.07E-07 | -0.008 | 0.355 |
PCOS | Total testosterone levels | IVW | 111.276 | 1.02E-18 | -0.005 | 0.502 |
PCOS | AMH | IVW | 6.169 | 1.87E-01 | 0.056 | 0.427 |
PCOS | Estrogn Receptor | IVW | 5.503 | 9.04E-01 | -0.039 | 0.404 |
PCOS | Female Infertility | IVW | 18.558 | 1.74E-02 | 0.044 | 0.307 |
PCOS | Infertility (associated with anovulation) | IVW | 53.374 | 9.13E-09 | 0.191 | 0.224 |
PCOS | Age at Menarche | IVW | 14.426 | 4.41E-02 | 0.004 | 0.834 |
PCOS | Age at menopause | IVW | 75.338 | 1.17E-11 | -0.055 | 0.667 |
PCOS | IGF-1 | IVW | 41.795 | 1.76E-05 | -0.013 | 0.114 |
PCOS | HOMA-IR | IVW | 11.825 | 3.73E-02 | 0.006 | 0.783 |
PCOS | Triglycerides | IVW | 5.089 | 4.05E-01 | 0.000 | 0.992 |
PCOS | Type 2 diabetes | IVW | 15.183 | 8.60E-02 | -0.009 | 0.692 |
PCOS | BC | IVW | 48.100 | 3.41E-08 | 0.003 | 0.859 |
PCOS | ER + BC | IVW | 16.200 | 9.40E-02 | 0.000 | 0.989 |
PCOS | ER- BC | IVW | 3.220 | 9.76E-01 | 0.020 | 0.349 |
ER | BC | IVW | 22.652 | 9.18E-02 | -0.018 | 0.086 |
ER + BC | MR Egger | 20.633 | 1.11E-01 | -0.034 | 0.018 | |
ER- BC | IVW | 15.813 | 3.95E-01 | -0.006 | 0.712 | |
AMH | BC | IVW | 52.702 | 2.12E-11 | -0.035 | 0.482 |
ER + BC | IVW | 38.885 | 1.84E-08 | -0.033 | 0.532 | |
ER- BC | IVW | 20.650 | 1.24E-04 | -0.026 | 0.669 | |
Age at Menarche | BC | IVW | 210.967 | 8.36E-17 | 0.009 | 0.128 |
ER + BC | IVW | 140.193 | 1.47E-08 | 0.012 | 0.065 | |
ER- BC | IVW | 138.685 | 2.31E-08 | 0.000 | 0.979 | |
Age at menopause | BC | IVW | 116.165 | 4.11E-09 | -0.005 | 0.243 |
ER + BC | IVW | 99.467 | 2.45E-08 | -0.002 | 0.696 | |
ER- BC | MR Egger | 61.421 | 1.92E-03 | -0.015 | 0.024 | |
IGF-1 | BC | IVW | 1764.000 | 1.18E-122 | 0.000 | 0.989 |
ER + BC | IVW | 1428.000 | 1.46E-75 | 0.000 | 0.838 | |
ER- BC | IVW | 988.000 | 3.95E-25 | -0.001 | 0.679 | |
Triglycerides | BC | IVW | 220.583 | 5.77E-23 | 0.005 | 0.127 |
ER + BC | IVW | 190.997 | 4.71E-18 | 0.005 | 0.175 | |
ER- BC | IVW | 87.466 | 1.12E-03 | 0.002 | 0.557 | |