Fig. 2
OVE cells colonize on the ovarian surface and p53R175H mutant OVE cells form ovarian tumors and progress to advanced-stage disease. A mCherry-OVE cells were injected into the left oviduct of female FVB/N mice and ovarian/tumor tissues were collected and weighed at 15, 30 and 60 days PTI (n = 3–4/group). B Immunohistochemical mCherry and H&E staining were performed on tumors collected at day 60. Arrows point to serous tissue (*p < 0.05, **p < 0.01, ***p < 0.001). Scale bars: 50 μm. Abbreviations: WT wild-type; MUT p53R175H mutant; KO Trp53 knockout