Fig. 4
p53R175H mutant OVE cells are more susceptible to simvastatin treatment compared to wild-type OVE cells and ovarian surface epithelial cells. A OVE (wild-type, p53R175H mutant and Trp53 gene knockout), B human FTE cells and C ovarian surface epithelial cells (n = 3/group) were treated with varying doses (0.00uM-1000uM) of simvastatin for 24 h and subjected to a resazurin sodium salt cell metabolic assay, then IC50 values were calculated. Bars represent mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)