Fig. 5

NEAT1 increased the expressions of angiogenesis-related molecules in xenografted human ovarian cancer tissues in nude mice. A-B Representative IHC images show the protein expressions of angiogenesis-related molecules in tumor tissues derived from SKOV-3 (A) or A2780 (B) cells. C-D The relative protein levels of the indicated angiogenesis-related molecules were summarized. The IHC staining intensities were normalized to the blank SKOV-3 (C) or A2780 (D) cells to calculate the fold-change of protein levels. E–F The RNA expression levels of NEAT1, miR-214-3p, and angiogenesis-related molecules in tumor tissues derived from SKOV-3 (E) or A2780 (F) cells were determined by qPCR. n = 5 for each group; *P < 0.05, **P < 0.01, between the indicated groups