Fig. 1

Screening and optimization of functional candidate genes related to ubiquitination of ovarian cancer and the expression level of UBE2S in ovarian cancer. A Venn diagrams of four GEO data sets related to ovarian cancer and ubiquitination-related genes (GSE38666, GSE40595, GSE18521, GSE26712). Six candidate genes were screened out (UBE2C, UBE2S, DTL, ITCH, CDC20, UBE2N). The expression level of UBE2S affects the prognosis of patients with ovarian cancer (UBE2S high expression = 388, UBE2S low expression = 169, p = 0.0081). B A box plot based on the differential expression levels of UBE2S in ovarian cancer and normal ovarian tissues in four GEO data sets. GSE38666, GSE40595, GSE18521, GSE26712. C Scatter plots of the differences in the mRNA expression levels of UBE2S in ovarian cancer and normal ovarian tissues in the TCGA dataset and GTEx dataset. D A box plot of the differences in the protein expression levels of UBE2S in ovarian cancer and normal ovarian tissues in the UALCAN database (Tumor = 100, Normal = 25). (*p < 0.05, ** p < 0.01, *** p < 0.001)