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Table 2 Oncologic and fertility outcomes of the eight patients

From: The pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary

NO

Lesions

Treatment for endometrial lesions(months)

Treatment response of endometrial lesions

Time to CR (months)

Maintenance treatment after CR

Treatment for ovarian tumors

Chemotherapy

Pregnancy

Interval time between CR and the initial pregnancy(months)

Live birth

Status

Follow-up (months)

Recurrence

Case1

SEOC

MA + LNG-IUD + MET(4)

NR (hysterectomy)

——

——

Right adnexectomy

No

——

——

——

Hysterectomy

NED (71)

No

Case2

SEOC

MA(8)

CR

7.7

Diane-35

Left cystectomy

No

1(IVF-ET)

10.6

1(38W CS)

Total hysterectomy + bilateral salpingo-oophorectomy

NED (55.7)

No

Case3

SEOC

MA + LNG-IUD + MET(8)

CR

6.6

Diane-35 + MET

Right adnexectomy

No

0(IVF-ET)

——

——

Diane + MET

NED (47.2)

No

Case4

SEOC

GnRH-a + letrozole(4)

CR

3.3

Diane-35 + MET

Left adnexectomy + pelvic lymph dissection + aortic lymph biopsy + peritoneal biopsy + omentum excision

No

0(Unmarried)

——

——

Diane + MET

NED (15.2)

No

Case5

EEA + BOT

MA + MET(4)

CR

1.8

LNG-IUD

Left adnexectomy after cystectomy

No

1(IVF-ET)

18.3

1(32W CS)

Total hysterectomy + right salpingectomy

NED (29.4)

No

Case6

EEA + BOT

GnRH-a + letrozole(4)

CR

3.8

Diane-35 + MET

Right cystectomy

No

1(IVF-ET)

12.5

1(38W CS)

lactational period

NED (24.4)

No

Case7

EAH + BOT

MA(6)

CR

3.8

Diane-35 + MET

Left cystectomy + right adnexectomy

No

0(Family planning)

——

——

LNG-IUD

NED (85.2)

No

Case8

EAH + BOT

MA + MET(3)

CR

1.5

Diane-35 + MET

Left adnexectomy

No

1(IVF-ET)

12.8

1(34W CS)

LNG-IUD

NED (53.9)

No

  1. Abbreviations: MA Megestrol acetate, LNG-IUD Levonorgestrel-releasing intrauterine device, MET Metformin, GnRHa Gonadotropin-releasing hormone agonist, NR No response, CR Complete response, IVF-ET In-vitro fertility embryo transplantation, CS Caesarean section, NED No evidence of disease