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Table 3 The effects of ASC and ASC-CM transplantation on follicular development after 4 weeks in the PCOS rat model

From: Administration of adipose-derived mesenchymal stem cell conditioned medium improves ovarian function in polycystic ovary syndrome rats: involvement of epigenetic modifiers system

Variables (number)

Groups

Sham

CTRL

ASC

ASC-CM

Primordial F

254.0 ± 8.560

257.2 ± 6.590

250.8 ± 5.338

247.5 ± 5.847

Primary F

143.3 ± 4.551

135.0 ± 5.939

124.3 ± 4.201

98.3 ± 4.551****###ΦΦ

Secondary F

35.5 ± 1.176

34.0 ± 1.183

31.0 ± 1.317

31.7 ± 1.054

Pre-antral F

16.2 ± 1.014

16.8 ± 0.654

10.8 ± 0.872**###

8.2 ± 0.749****####

Antral F

12.8 ± 1.376

15.0 ± 2.463

20.3 ± 1.282

24.2 ± 3.439*#

Pre-ovulatory F

10.5 ± 0.428

10.2 ± 0.749

11.3 ± 0.615

11.5 ± 0.563

Atretic F

37.7 ± 4.287

40.5 ± 4.023

19.0 ± 2.251**###

17.5 ± 1.607**###

Corpus luteum

8.8 ± 0.924

6.7 ± 1.133

10.7 ± 0.375#

13.7 ± 0.815**####

Cysts

16.2 ± 1.400

13.2 ± 1.116

12.3 ± 1.085

6.2 ± 0.703****###ΦΦ

  1. Data are expressed as the mean ± SEM. *shows significant differences vs Sham (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.000). #shows significant differences vs CTRL group (#P ≤ 0.05, ##P ≤ 0.01, ###P ≤ 0.001, and ####P ≤ 0.000). Φ shows significant differences vs ASC group (ΦΦ P ≤ 0.01). Data were analyzed by one-way ANOVA followed by Tukey’s post hoc test. Abbreviations: CTRL, Control group; ASC, Adipose stem cell group; ASC-CM, Adipose stem cell-conditioned media group
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Journal of Ovarian Research

ISSN: 1757-2215

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