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Table 4 Association between quartiles of SII and laboratory data among the whole participants (N = 966)

From: The association between systemic immune-inflammation index and in vitro fertilization outcomes in women with polycystic ovary syndrome: a cohort study

Variable

Crude model (β, 95%CI, P)

Minimally adjusted model(β, 95%CI, P)

Fully adjusted model(β, 95%CI, P)

No. of available embryos

 SII quartile

   Q1

Ref

Ref

Ref

   Q2

0.86 (0.08, 1.64), 0.032

0.64 (-0.08, 1.36), 0.082

0.74 (0.02, 1.46), 0.046

   Q3

0.76 (-0.02, 1.54), 0.058

0.07 (-0.64, 0.79), 0.838

0.12 (-0.60, 0.84), 0.748

   Q4

0.11 (-0.68, 0.89), 0.788

-0.72 (-1.45, 0.01), 0.052

-0.71 (-1.44, 0.02), 0.056

   Log SII

0.27 (-0.42, 0.95), 0.445

-0.56 (-1.19, 0.08), 0.089

-0.57 (-1.21, 0.07), 0.079

  P for trenda

0.8601

0.0195

0.0187

Available embryo rate

 SII quartile

   Q1

Ref

Ref

Ref

   Q2

0.03 (-0.01, 0.07) 0.163

0.02 (-0.02, 0.07) 0.247

0.03 (-0.02, 0.07) 0.239

   Q3

0.01 (-0.03, 0.06) 0.507

0.01 (-0.03, 0.06) 0.525

0.01 (-0.03, 0.06) 0.541

   Q4

-0.10 (-0.14, -0.06) < 0.0001

-0.10 (-0.15, -0.06) < 0.0001

-0.11 (-0.15, -0.06) < 0.0001

   SII Log

-0.08 (-0.11, -0.04) < 0.0001

-0.08 (-0.12, -0.04) < 0.0001

-0.08 (-0.12, -0.04) < 0.0001

  P for trenda

 < 0.0001

 < 0.0001

 < 0.0001

High-quality embryos

 SII quartile

  Q1

Ref

Ref

Ref

  Q2

0.46 (-0.15, 1.08) 0.136

0.31 (-0.28, 0.89) 0.303

0.33 (-0.25, 0.92) 0.266

  Q3

0.54 (-0.07, 1.15) 0.084

0.04 (-0.55, 0.62) 0.903

0.05 (-0.53, 0.64) 0.856

  Q4

0.41 (-0.20, 1.02) 0.185

-0.17 (-0.76, 0.42) 0.569

-0.17 (-0.76, 0.43) 0.583

   Log SII

0.48 (-0.05, 1.01) 0.0789

-0.09 (-0.60, 0.42) 0.733

-0.09 (-0.60, 0.43) 0.745

  P for trenda

0.182

0.411

0.417

  1. Tests for linear trend were conducted by assigning median values of each quartile of systemic immune-inflammation index as a continuous variable in the models
  2. Crude model: did not adjust other covariants
  3. Minimally adjusted model: adjusted age; AMH; BMI; AFC
  4. Fully adjusted model: adjusted age; Basal FSH; Basal E2; Basal LH; AMH;AFC; Total Gn dose; Duration of Gn; E2 on HCG start day; P on HCG start day
  5. Abbreviations: CI Confidence interval, Ref Reference, SII Systemic immune-inflammation index