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Table 2 Comparison of the morphokinetic parameters and the incidence of morphological dysmorphisms and irregular cleavages among embryos classified by ploidy status

From: The morphokinetic signature of human blastocysts with mosaicism and the clinical outcomes following transfer of embryos with low-level mosaicism

 

Euploid

Mosaic

Mosaic with aneuploid

Aneuploid

P value

tPB2 (h)

3.37 (2.90, 4.00)

3.40 (3.30, 4.06)

3.13 (2.68, 4.23)

3.50 (3.91, 4.14)

0.275

tPNa (h)

9,73 (8.48, 11.48)

9.46 (8.21, 10.98)

9.72 (8.37, 11.67)

9.90 (8.50, 11.57)

0.204

tPNf (h)

22.38 (20.75, 23.89)

22.12 (20.72, 23.75)

22.67 (20.99, 24.47)

22.36 (20.68, 24.28)

0.339

t2 (h)

24.80 (23.12, 26.45)

24.37 (23.08, 26.14)

25.17 (23.89, 27.11)

24.80 (23.10, 26.73)

0.075

t3 (h)

35.54 (33.24, 37.77)

35.56 (33.53, 37.33)

35.93 (34.05, 38.09)

35.38 (33.14, 38.02)

0.564

t4 (h)

36.35 (34.41, 38.65)

36.41 (34.16, 38.53)

37.24 (35.19, 39.25)

36.54 (34.26, 39.10)

0.327

t5 (h)

49.27 (45.48, 52.59)

49.67 (45.91, 52.68)

49.45 (45.20, 53.04)

49.16 (45.13, 53.00)

0.888

t6 (h)

51.07 (47.45, 54.64)

51.77 (47.57, 55.01)

51.48 (48.10, 56.38)

50.82 (47.25, 54.97)

0.618

t7 (h)

53.17 (49.48, 57.36)

52.91 (48.58, 57.01)

53.96 (50.36, 59.83)

52.49 (48.47, 56.92)

0.119

t8 (h)

55.97 (51.17, 61.89)ab

56.72 (51.47, 62.89)ab

59.67 (52.54, 67.20)a

55.00 (50.69, 61.09)b

0.040

tC (h)

74.66 (66.28, 81.12)

73.33 (67.49, 809.55)

77.41 (69.17, 81.54)

73.16 (65.81, 80.23)

0.238

tM (h)

82.17 (76.89, 87.89)ab

80.49 (74.24, 85.81)a

84.57 (79.81, 89.95)b

81.77 (75.70, 88.29)ab

0.027

tSB (h)

93.31 (88.04, 100.02)

93.74 (87.89, 98.90)

97.95 (90.05, 101.93)

93.71 (88.30, 100.49)

0.135

tHB (h)

104.34 (97.96, 111.20)a

104.90 (99.77, 113.21)ab

110.14 (102.30, 113.51)b

105.44 (98.94, 111.05)ab

0.030

S2 (h)

0.50 (0.25, 1.00)

0.50 (0.25, 1.00)

0.50 (0.25, 1.25)

0.50 (0.25, 1.25)

0.775

S3 (h)

5.25 (3.00, 14.25)ab

6.00 (3.00, 11.26)ab

10.18 (4.34, 15.45)a

4.50 (2.75, 10.75)b

0.005

CC3 (h)

13.59 (12.09, 15.52)

14.02 (12.27, 15.78)

14.00 (12.25, 15.51)

13.50 (12.01, 15.25)

0.468

KIDScore

5.70 (4.70, 6.90)b

5.50 (4.50, 6.60)b

4.55 (4.00, 5.70)a

5.50 (4.60, 6.50)b

3.60E-05

MN2

    

0.289

 Yes

112 (29.02%)

21 (21.21%)

23 (34.33%)

106 (28.57%)

 

 No

274 (70.98%)

78 (78.79%)

44 (65.67%)

265 (71.43%)

 

Frag-2

    

0.177

 Yes

59 (15.28%)

14 (14.14%)

6 (8.96%)

39 (10.51%)

 

 No

327 (84.72%)

85 (85.86%)

61 (91.04%)

332 (89.49%)

 

Direct cleavage

    

0.500

 Yes

19 (4.92%)

4 (4.04%)

6 (8.96%)

18 (4.85%)

 

 No

367 (95.08%)

95 (95.96%)

61 (91.04%)

353 (95.15%)

 

Uneven cleavage-2

    

0.177

 Yes

33 (8.55%)

7 (7.07%)

10 (14.93%)

26 (7.01%)

 

 No

353 (91.45%)

92 (92.93%)

57 (85.03%)

345 (92.99%)

 

Reverse cleavage

    

6.63E-06

 Yes

0 (0%)

3 (3.03%)

2 (2.99%)

12 (3.23%)

 

 No

386 (100.00%)

96 (96.97%)

65 (97.01%)

359 (96.77%)

 
  1. Data are presented as Median (interquartile range) for continuous variable or Number (%) for categorical variable
  2. P values were calculated using Kruskal–Wallis tests and Bonferroni post hoc for continuous variable and χ2 tests for categorical variable
  3. Median with common superscripts across columns are not significantly different
  4. Bolded P values reached statistical significance
  5. tPB2 time of polar body emission, tPNa time of pronuclei appearance, tPNf time of pronuclear fade out, t2, t3, t4, t5, t6, t7, t8 the time to reach 2, 3, 4, 5, 6, 7,8 cells, tC time to get compacted, tM time to reach morula, tSB time of starting blastulation, tHB time of the hatched blastocyst, s2, s3 time of the second, third synchrony; cc3 time of the third cell cycle, MN2 multinucleation at the 2-cell stage, Frag-2 fragmentation at the 2-cell stage