Table 3 Multivariate logistic regression analysis to evaluate the effects of time-lapse parameters on embryonic ploidy status

Variables

Mosaic vs. euploid (ref)

Mosaic vs. mosaic with aneuploid (ref)

Mosaic vs. aneuploid (ref)

OR [95% CI]

P value

OR [95% CI]

P value

OR [95% CI]

P value

PGT indication (PGT-A vs. PGT-SR)

0.65 (1.10, 0.39)

0.109

0.22 (0.09, 0.56)

1.23E-03

0.20 (0.11, 0.37)

2.31E-07

Female age (year)

0.99 (0.90, 1.11)

0.940

1.08 (0.92, 1.28)

0.354

0.95 (0.85, 1.07)

0.415

Male age (year)

0.99 (0.93, 1.08)

0.965

0.95 (0.85, 1.05)

0.304

0.99 (0.89, 1.09)

0.779

Basal estradiol (pg/ml)

1.01 (0.99, 1.02)

0.062

1.03 (1.01, 1.05)

0.005

1.02 (1.00, 1.03)

0.009

During of stimulation days

0.81 (0.67, 0.99)

0.042

0.95 (0.69, 1.32)

0.762

0.89 (0.71, 1.23)

0.336

Gonadotropin dose (ampoules, 75 IU/ampoule)

0.99 (0.97, 1.02)

0.485

0.97 (0.92, 1.02)

0.217

0.96 (0.94, 0.99)

0.017

t8 (h)

1.04 (0.99, 1.09)

0.112

1.02 (0.94, 1.10)

0.662

1.04 (0.99, 1.09)

0.063

tM (h)

0.95 (0.92, 0.98)

0.002

0.92 (0.87, 0.98)

0.005

0.95 (0.92, 0.99)

0.005

tHB (h)

1.03 (0.99, 1.07)

0.203

1.06 (0.99, 1.14)

0.086

1.02 (0.98, 1.07)

0.265

S3 (h)

0.99 (0.94, 1.04)

0.603

1.00 (0.93, 1.08)

0.945

1.01 (0.96, 1.06)

0.726

KIDScore

0.93 (0.74, 1.18)

0.551

1.88 (1.21, 2.91)

0.005

1.07 (0.84, 1.36)

0.582

Reverse cleavage (no vs. yes)

9.36E6 (1.71E6, 5.13E7)

< 0.001

3.20 (0.19, 54.96)

0.423

1.77 (0.21, 6.65)

0.854

Variables

Mosaic with aneuploid vs. euploid (ref)

Mosaic with aneuploid vs. aneuploid (ref)

Aneuploid vs. euploid (ref)

OR [95% CI]

P value

OR [95% CI]

P value

OR [95% CI]

P value

PGT indication (PGT-A vs. PGT-SR)

2.27 (1.22, 4.35)

0.009

1.33 (0.68, 2.62)

0.404

3.32 (2.32, 3.32)

4.48E-11

Female age (year)

0.98 (0.87, 1.10)

0.722

0.93 (0.83, 1.04)

0.930

1.07 (1.00, 1.14)

0.039

Male age (year)

1.03 (0.96, 1.11)

0.371

1.05 (0.97, 1.14)

0.209

0.98 (0.93, 1.03)

0.441

Basal estradiol (pg/ml)

0.99 (0.97, 1.00)

0.107

0.99 (0.98, 1.01)

0.405

0.99 (0.98, 1.00)

0.042

During of stimulation days

0.96 (0.77, 1.20)

0.714

1.03 (0.81, 1.31)

0.810

0.90 (0.79, 1.02)

0.101

Gonadotropin dose (ampoules)

1.01 (0.98, 1.05)

0.440

0.99 (0.96, 1.02)

0.411

1.03 (1.01, 1.05)

4.07E-04

t8 (h)

1.02 (0.97, 1.07)

0.534

1.01 (0.96, 1.06)

0.771

1.00 (0.97, 1.03)

0.99

tM (h)

0.99 (0.95, 1.03)

0.464

0.99 (0.96, 1.04)

0.889

0.99 (0.97, 1.02)

0.528

tHB (h)

1.00 (0.95, 1.04)

0.843

1.00 (0.96, 1.05)

0.897

1.00 (9.78, 1.03)

0.85

S3 (h)

1.00 (0.95, 1.05)

0.904

1.03 (0.98, 1.08)

0.215

0.97 (0.94, 0.99)

0.036

KIDScore

0.62 (0.48, 0.82)

6.47E-04

0.67 (0.51, 1.88)

0.004

0.92 (0.80, 1.07)

0.297

Reverse cleavage (no vs. yes)

7.46E6 (8.85E5, 6.33E7)

< 0.001

1.72 (0.20, 14.79)

0.622

-

-