Table 1 Summary of stem cells for POI therapy
Type | Author | Year | Mechanisms | Outcome |
|---|---|---|---|---|
Bone marrow stem cells (BMSCs) | S. Abd-Allah et al | 2013 | The secretion of vascular endothelial growth factor (VEGF) increased | The level of FSH decreased, the number of follicles and estrogen levels increased |
J. Guo et al | 2013 | 1. Up regulation of c-myc proto oncogene mRNA 2. Down regulation of bcl 2 related X protein (Bax) and cyclin dependent kinase inhibitor 1a (p21) | Inhibition of granulosa cell apoptosis | |
Y. Zhang et al | 2022 | Exosomal mir-644-5p and mir-144-5p regulate p53 and target PTEN | Inhibition of granulosa cell apoptosis | |
X. Fu et al | 2017 | MiRNA down regulates programmed cell death protein 4 (PDCD 4) and PTEN | Repair ovarian structure and function | |
Umbilical cord mesenchymal stem cells (UC MSCs) | L. Cui et al | 2020 | Transforming growth factor- β/ Smad3 signaling pathway regulates ovarian stromal cell differentiation | Inhibit the occurrence and development of ovarian fibrosis in POI rats |
C. Ding et al | 2020 | Exosomal mirna-17-5p regulate sirt7 | Improve ovarian function | |
Menstrual blood derived mesenchymal stem cells (MenSCs) | Z. Yan et al | 2019 | Increase the secretion of fibroblast growth factor 2 | Avoid granulosa cell apoptosis |
Human amniotic fluid stem cells (AFSCs) | X. Yu et al | 2014 | Potential for differentiation into primordial follicle oocytes | Improve ovarian function |
G. Xiao et al | 2016 | Exosomes mir-10a and miR-146a can inhibit follicular atresia | Improve the survival rate of granulosa cells | |
Placental derived mesenchymal stem cells (PMSCs) | H. Zhang et al | 2018 | Increased serum AMH and estrogen secretion | Inhibit follicular atresia and granulosa cells apoptosis |
J. Seok et al | 2020 | Up regulation of antioxidant factors | Inhibit granulosa cells apoptosis | |
N. Yin et al | 2018 | Regulation of the ratio between Th17 / Treg and Th17 / T C17 cells through PI3K / Akt signaling pathway | Inhibit granulosa cells apoptosis | |
H. Li et al | 2019 | Inhibition of endoplasmic reticulum stress inositol requires enzyme 1 signaling pathway | Inhibit granulosa cells apoptosis | |
Amniotic mesenchymal stem cells (AMSCs) | L. Ling et al | 2017 | Reduce the expression of inflammatory cytokines | Inhibit the occurrence and development of ovarian inflammation in POI rats |
C. Ding et al | 2020 | Exosomal mir320a inhibit ROS production by regulating sirtuin4 | Alleviating POI | |
Adipose derived stem cells (ADSCs) | P. Terraciano et al | 2014 | Induce angiogenesis | Restore the number of follicles and repair the damage of ovary |
B. Huang et al | 2018 | Exosomes regulate the Smad pathway | Restore ovarian function in patients with POI | |
Induced oogonial stem celled (iOSC) | O. Celik et al | 2020 | Mesenchymal stem cells (MSCs) were cultured and isolated in vitro, and OSC-specific genes were transferred into MSCs to produce iOSC | Intraovarian transplantation of iOSCs can produce oocyte like cells with haploid chromosomes |