Fig. 1

Genomic context and structure of GSN isoforms. (A) The pGSN, cGSN, and Gelsolin-3 are three well known isoforms of GSN, which are encoded by single gene and formed by alternative splicing and different transcriptional sites. Three isoforms are characterized by arrangement of 5`-end; pGSN 5`-end is made up of exon 3-intron-exon 4 while exon 3 make up untranslated region (UTR) and codes for signaling peptide, cGSN 5`-end made up of exon 1- intron- exon 2 – intron – exon 4, while exons 1 and 2 make UTR, 5`-end of Gelsolin-3 is made up of region between exon 3 and 4 which also make its UTR. (B) All three isoforms have similar 733 amino acids, pGSN and Gelsolin-3 have 24 and 11 extra amino acids at N-terminus, respectively, which differentiate them from cGSN