Table 3 Subgroup analysis of early and late onset HDP, corrected for age and BMI
Controls n = 81 | Early onset HDP < 34 weeks n = 83 | p-value < 34 weeks vs controls | Late onset HDP ≥ 34 weeks n = 61 | p-value ≥ 34 weeks vs controls | p-value < 34 vs ≥ 34 weeks | |
|---|---|---|---|---|---|---|
Age (years) | 35 [30–38] | 32 [29–35] | 0.001* | 31 [29–34] | < 0.001* | 0.570 |
Height (meters) | 1.69 [1.65–1.74] | 1.68 [1.62–1.73] | 0.076 | 1.69 [1.65–1.73] | 0.408 | 0.365 |
Weight (kilograms) | 65.0 [59.0–74.0] | 77.0 [66.0–85.0] | < 0.001* | 68.0 [61.5–76.0] | 0.284 | 0.001* |
BMI (kilogram/meter2) | 23.0 [21.0-25.3] | 26.4 [23.7–30.8] | < 0.001* | 23.6 [21.7–26.7] | 0.234 | < 0.001* |
Gravidity (n) | 2 (1–4) | 1 (1–9) | < 0.001* | 1 (1–5) | < 0.001* | 0.951 |
Parity (n) | 2 (1–4) | 1 (1–3) | < 0.001* | 1 (1–3) | < 0.001* | 0.580 |
Birthweight (grams) | 3440 [3027–3780] | 1570 [1070–1900] | < 0.001* | 2770 [2413–3118] | < 0.001* | < 0.001* |
Gestational age (days) | 280 [273–286] | 229 [208–238] | < 0.001* | 260 [255–271] | < 0.001* | < 0.001* |
Time postpartum (weeks) | 128 [93–258] | 52 [30–92] | < 0.001* | 52 [31–86] | < 0.001* | 0.963 |
AMH level (µg/L) | 2.0 [0.7–3.5] | 2.4 [0.9–4.5] | 0.215 | 2.8 [1.5–4.3] | 0.025* | 0.330 |
Glucose (mmol/L) | 4.8 [4.6–5.1] | 5.0 [4.8–5.2] | 0.014 | 4.9 [4.8–5.2] | 0.103 | 0.872 |
Insulin (mU/L) | 4.3 [2.8–6.9] | 8.5 [6.0-14.6] | < 0.001* | 7.3 [5.2–9.9] | < 0.001* | 0.571 |
Systolic BP (mmHg) | 108 [103–114] | 114 [109–121] | 0.017* | 113 [108–120] | 0.001* | 0.508 |
Diastolic BP (mmHg) | 69 [63–75] | 72 [68–78] | 0.002* | 71 [67–75] | 0.004* | 0.783 |
MAP (mmHg) | 83 [78–89] | 88 [83–95] | 0.004* | 87 [82–92] | 0.004* | 0.954 |
Total cholesterol (mmol/L) | 4.5 [4.1–4.9] | 4.5 [3.9–5.2] | 0.408 | 4.5 [4.1–5.1] | 0.673 | 0.923 |
HDL cholesterol (mmol/L) | 1.6 [1.3–1.8] | 1.4 [1.2–1.7] | 0.154 | 1.4 [1.2–5.1] | 0.865 | 0.430 |
Triglycerides (mmol/L) | 0.7 [0.6–0.9] | 0.9 [0.7–1.2] | 0.025* | 0.9 [0.7–1.3] | < 0.001* | 0.050 |