Table 2 Effect of SNPs on stability of mutated proteins predicted using I-Mutant at 25°C and pH = 7
# | SNP ID | RI | DDG (kcal/mol) | Stability |
|---|---|---|---|---|
ESR1 | ||||
 1 | rs1583384537 | 0 | 0.03 | increase |
 2 | rs761613029 | 6 | -0.10 | decrease |
 3 | rs778449608 | 8 | -1.01 | decrease |
 4 | rs866869178 | 7 | -0.77 | decrease |
 5 | rs188957694 | 4 | -1.28 | decrease |
 6 | rs1584799119 | 2 | 0.17 | increase |
 7 | rs1131692059 | 8 | -1.10 | decrease |
 8 | rs758798083 | 2 | -0.21 | decrease |
ESR2 | ||||
 1 | rs1450198518 | 6 | 0.28 | increase |
 2 | rs754945292 | 6 | -0.83 | decrease |
 3 | rs1249242790 | 7 | -1.71 | decrease |
 4 | rs1414263985 | 5 | -0.10 | decrease |
 5 | rs78255744 | 3 | 0.23 | increase |
 6 | rs768924970 | 2 | -0.23 | decrease |